The Prada Group did not comment.
Zambernardi, 59, was named to his current role in November 2002 for all divisions ranging from ready-to-wear to footwear and accessories.
He has been collaborating with the brand since 1981. He was promoted shoe design director in 1997 and design fashion coordinator in 1999.
While known to keep a low profile, Zambernardi is very much respected in fashion circles and is considered influential within the company. He also worked with Prada and her husband Patrizio Bertelli, group chairman and executive director, on the development of image strategies.
Prada Group, as reported, has been enjoying strong brand momentum at both Prada and Miu Miu, which helped register strong profitability and revenues in the first half. In the six months ended June 30, group net profit soared 62 percent to 305 million euros and revenues amounted to 2.23 billion euros, up 17 percent compared with the same period last year.
Andrea Guerra joined the group as chief executive officer in January.